Research Projects

A new concept for the direct functionalization of carbon-hydrogen (C-H) bonds has been proposed, offering a more streamlined approach to increasing molecular complexity and enabling late-stage modifications of drug-like compounds without extensive functional group transformations. Since 2014, the sulfur (VI) fluoride exchange (SuFEx) reaction has become a key "click" reaction, widely applied in organic synthesis, materials science, and pharmaceutical chemistry. Photoredox catalysis is an innovative and powerful tool in organic synthesis that can provide efficient and greener opportunities for industrial and academic research. Photoredox catalysis combined with chiral H-bonding asymmetric catalysis, can facilitate an enantioselective radical addition enabling the direct asymmetric functionalization of C(sp3)-H bonds. Moreover, the presented concept would give a straightforward, efficient, and sustainable solution for aromatic and late-stage drug fluorosulfonylation. The growing environmental concerns demand a new concept, which would be: transition metal-free, unactivated C-H bond functionalization directly, simple, and atom-economic. The proposed concept would be capable enough to overcome the existing shortcomings and is expected to provide a straightforward solution for the efficient catalyst development for the direct C-H bond fluorosulfonylation and further useful synthetic transformation.