IN374290: An improved process for the synthesis of ivacaftor

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The disclosed an improved process for the synthesis of ivacaftor starting from indole acetic acid ester which can be performed in batch as well as continuous flow synthesis. The invention further disclosed to a continuous process for the synthesis of compound of formula (II) or formula (III) from compound of formula (I) in continuous flow reactor.

Patent No:: IN374290
Application No:: 201611018491
Filing Date:: 30-05-2016
Issue Date:: 13-08-2021
Applicant:: CSIR-National Chemical Laboratory (CSIR-NCL), Pune
Inventor(s):: Dumbala Srinivasa Reddy; Amol Arvind Kulkarni; Vasudevan Natarajan; Mrityunjay Keshavprasad Sharma
IPC Classification:: A61K 31/00
Country:: India

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