The invention provides compounds of general formula (3) as useful potential antitumour agents against human cancer cell lines. The invention further provides a process for the synthesis of 4?-acrylamidopodophyllotoxin congeners of general formula (3), wherein R and R1 are an aryl group and R is selected from 3,4,5-trimethoxyphenyl or 2-methoxy phenyl and R1 is selected from the group consisting of 4-hydroxy-3-methoxyphenyl, 3-hydroxy-4-methoxyphenyl, 4-fluoro-3-methoxyphenyl, 3-fluoro-4-methoxyphenyl, 2-fluoro-5-methoxyphenyl, 2-fluoro-4-methoxyphenyl, 4-hydroxy-3-nitrophenyl, 4-methoxy-3-nitrophenyl, 4-nitrophenyl, 3-nitrophenyl, 2-nitro phenyl, 4-methoxyphenyl, 3-methoxyphenyl and 4-hydroxyphenyl.
- Patent No:
- US8673969
- Application No:
- 13/883938
- Filing Date:
- 07-05-2013
- Issue Date:
- 18-03-2014
- Applicant:
- CSIR-Indian Institute of Chemical Technology (CSIR-IICT)
- Inventor(s):
- Ahmed, Kamal (Hyderabad, In); Paidakula, Suresh (Hyderabad, In); Banala, Ashwini Kumar (Hyderabad, In); Reddy, Adla Malla (Hyderabad; In), Reddy, Papagiri Venkat (Hyderabad, In)
- IPC Classification:
- A61K 31/335, C07D 493/04
- Country:
- United States of America
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