IN272479: A process for the preparation of optically active n-benzyl-3-hydroxypyrrolidines
Abstract
The invention relates to a facile, highly efficient and economical process for the preparation of optically active N-benzyl-3-hydroxypyrrolidine in high yield from a naturally occurring alkaloid vasicine. The natural alkaloid vasicine is used as a precursor of (S)-N-benzyl-3-hydroxypyrrolidine and (R)-N-benzyl-3 hydroxypyrrolidines which can easily be sourced from the medicinal plant Adatoda vasica by the method known in the art and transformed to optical isomers (R) and (S)-N-benzyl-3-hydroxypyrrolidine by the method described in the present invention.
Filing Date:
24-11-2008
Issue Date:
04-04-2016
Applicant:
CSIR-Indian Institute Of Integrative Medicine (CSIR-IIIM), Jammu
Patent No:
IN272479
Application No:
2648DEL2008
Inventor(s):
Subhash Chandra Taneja, Mushtaq Ahmad Aga, Brijesh Kumar, Vijay Kumar Sethi, Samar Singh Andotra, Ghulam Nabi Qazi
IPC Classification:
C07D
Country:
India
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