IN265106: Process for the synthesis of enantiomerically pure alkys (s)-4-bromo-3-hydroxybutanoate
Abstract
The invention provides an improved synthesis of enantiomerically pure Alkyl (Methyl or Ethyl) (S)-4-Bromo-3-hydroxybutanoate been achieved. The synthetic strategy features use of D-erythronolactone as the starting substrate. Its ready conversion to Alkyl 2,4-dibromo-3-hydroxybutanoate and selective C-2 debromination affords optically pure Alkyl (,S')-4-Bromo-3-hydroxybutanoate. The title compound is a key intermediate in arriving at the substrates for HMG-coA reductase inhibitors.
Filing Date:
01-11-2004
Issue Date:
06-02-2015
Applicant:
CSIR(SCH)
Patent No:
IN265106
Application No:
2174DEL2004
Inventor(s):
Indrapal Singh Aidhen
IPC Classification:
C07C 67/00
Country:
India
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