IN303076: Protein fusion constructs possessing thrombolytic and anticoagulant properties
Abstract
The invention discloses novel hybrid proteins that have both plasminogen activator and anti-thrombotic properties, including clot specific action, that renders these as highly advantageous for the treatment of circulatory disorders involving fibrin clot formation due to underlying tissue damage in the blood vessels leading to myocardial infarction, strokes etc. Also disclosed are new proteins, and methods of obtaining the same, that help to dissolve blood clots by activating plasminogen in a plasmin or thrombin dependent manner and also inhibit both the activity and generation of thrombin through the intrinsic pathway of blood coagulation.
Filing Date:
29-08-2011
Issue Date:
13-11-2018
Applicant:
CSIR-Institute of Microbial Technology (CSIR-IMT), Chandigarh
Patent No:
IN303076
Application No:
06563DELNP2011
Inventor(s):
Neeraj Maheshwari; Girish Sahni
IPC Classification:
C12N9/64, C12N9/48, C12N9/52
Country:
India
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