IN276287: An improved process for preparation of trans-3, 4-diarylchroman
Abstract
The invention describes an improved and advantageous process of preparation of trans 3,4-diarylchroman and similar derivatives thereof, useful as anti-fertility, anti-osteoporotic and breast cancer drugs. Condensation of arenes with 2,2-dialkyl-3-aryl chromene in the presence of a Lewis acid furnishes trans -3,4-diaryl-2,2-dialkylchroman exclusively. Thus trans-2,2-dimethyl-3-phenyl-4-(4-hydroxyphenyl) chroman, the precursor of Ormeloxifene is obtained in excellent yield by hydroarylation of phenol with 2,2-dimethyl-3-phenyl chromene.
Filing Date:
17-12-2007
Issue Date:
10-10-2016
Applicant:
CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow
Patent No:
IN276287
Application No:
2639DEL2007
Inventor(s):
Devi Prasad Sahu
IPC Classification:
A61K 31/00, C07D 311/58
Country:
India
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