The invention provides peptides which specifically react with B-subunit of Plasmodium falciparum vacuolar-H+ATPase (V-H+ATPase). The peptides were identified by panning phage display peptide libraries with recombinant B subunit of P.falciparum V-H+ ATPase. The selected phages specifically react with P.falciparum infected cells and corresponding free peptides inhibit parasite growth in vitro. The identified peptides can be used for therapy of malaria and other diseases caused by pathogens expressing B subunit of V-H+ ATPase.
Filing Date:
05-09-2011
Issue Date:
24-10-2019
Applicant:
CSIR-Institute of Microbial Technology (CSIR-IMT), Chandigarh
Patent No:
IN323612
Application No:
2544DEL2011
Inventor(s):
Grish C Varshney; Kaliannan Ganesan; Ashu Shah; Shailendra K Gautam; Rakesh Bhatia
IPC Classification:
C12M
Country:
India
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