ZA201209026: 6-methyl-4-phenyl-5-(phenyl or cycloalkyl)carbamoyl-1,2,3,4-tetrahydropyrimidin-2-one derivatives as antitubercular agents

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The invention discloses antitubercular compounds selected from tetrahydropyrimidones/ tetrahydrothiopyrimidone derivatives of formula A and its pharmaceutically acceptable salts for the treatment of Mycobacterium in the dormant phase. Formula A wherein, R is H, halogen, dihalogen, O-alkyl, di-O-alkyl, R1 is phenyl, chlorophenyl, nitrophenyl, diclorophenyl, cycloalkyl, preferably cyclohexyl, X is O or S.

Patent No:: ZA201209026
Application No:: 2012/09026
Filing Date:: 29-11-2012
Issue Date:: 31-07-2013
Applicant:: CSIR-National Chemical Laboratory (CSIR-NCL), Pune
Inventor(s):: Dhiman Sarkar, Sampa Sarkar, Rohit Ramesh Joshi, Vijay Murlidhar Khedkar, Raghuvir Ramakant Pissurlenkar, Evans Cliffton Coutinho, Anamik Kantilal Shah
IPC Classification:: A61K A61P, C07D
Country:: South Africa

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