The invention relates to newer generation of triazoles, tetrazoles, isoxazoles, urea and sulphonamide functionalities containing 6-nitro-2,3-dihydronitroimidazooxazoles agents of formula 1, their method of preparation, and their use as drugs for treating Mycobacterium tuberculosis, MDR-TB and XDR-TB either alone or in combination with other anti-tubercular agents. In this invention, new generation 6-nitro-2,3-dihydronitroimidazooxazoles agents also show acceptable pharmacokinetic properties and synergistic or additive effects with known anti-tubercular drugs.
- Patent No:
- US9845330
- Application No:
- 15/027137
- Filing Date:
- 04-04-2016
- Issue Date:
- 19-12-2017
- Applicant:
- CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM), Jammu
- Inventor(s):
- Parvinder Pal Singh, Gurunadham Munagala, Kushalava Reddy Yempalla, Inshad Ali Khan, Nitin Pal Kalia, Vikrant Singh Rajput, Amit Nargotra, Sanghapal Damodhar Sawant, Ram Asrey Vishwakarma
- IPC Classification:
- C07D 049804, A61K 0031424, A61K 00314439, A61K 0031454, A61K 0031496, A61K 00315377, A61K 004506
- Country:
- United States of America
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