The invention provides compounds of general formula (4a-z and 4aa-4ae) as useful potential antitumour agents against human cancer cell lines. It further provides a process for the synthesis of new 4-aza-2,3-didehydropodophyllotoxin compounds (4a-z and 4aa-4ae). R = 2,4 dimethoxy 5-pyrimidyl, 5-indyl,2-methyl-5-indyl,5-indazolyl, 6-benzthiazolyl,2-methyl-6-benzthiazolyl, 2-mercapto-5-imidazolyl, 5-triazolyl,3-(4-methoxyphenyl)5-isoxazolyl,3-(4-chlorophenyl)5-isoxazolyl,2,3,4-trimethoxyphenyl, R1 =3,4,5-trimethoxyphenyl,4-hydroxy-3-methoxyphenyl,3-hydroxy-4-methoxyphenyl,4-fluoro-3-methoxyphenyl,3-nitro-4-rnethoxyphenyl, 2-fluoro-4-methoxyphenyl
- Patent No:
- IN304893
- Application No:
- 2887DEL2010
- Filing Date:
- 06-12-2010
- Issue Date:
- 24-12-2018
- Applicant:
- CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad
- Inventor(s):
- Ahmed Kamal, Paidakula Suresh, Banala Ashwini Kumar, Adla Mallareddy, Papagari Venkat Reddy, Jaki Rasheed Tamboli
- IPC Classification:
- C07K 5/00
- Country:
- India
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