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IN341911: A highlyenantioselective synthesis of (+)-sertraline

The invention discloses substituted diphenyloxiranes and process for synthesis thereof.  The present invention also provides a process for production of enantiomerically pure anti - 3,3-diphenylmethyloxirane and  anti-3,3’-diphenylpropane-1,2-diol from racemic anti -3,3’-diphenylmethyloxirane using hydrolytic kinetic resolution. Further it provides a process for preparation of enantioselective (+) -Sertraline from anti - 3,3’ –dipheny lpropane-1,2-diol.
Patent No:
IN341911
Application No:
3482DEL2014
Filing Date:
01-12-2014
Issue Date:
17-07-2020
Applicant:
CSIR-National Chemical Laboratory (CSIR-NCL), Pune
Inventor(s):
Gurunath Mallappa Suryavanshi, Arumugam Sudalai, Rohit Balkrishna Kamble
IPC Classification:
B0131/00, F16C32/06, F16C33/02, F16C33/10, B29C67/04, G10K11/16, G10K11/172, F16C
Country:
India
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