US9199930: Process for the preparation of (s)-2-ethyl-n-(1-methoxypropan-2-yl)-6-methyl aniline

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Disclosed herein is a novel process for the preparation of (S)-2-ethyl-N-(1-methoxypropan-2-yl)-6-methyl aniline [(S)-1]. Particularly, the invention relates to the synthesis of (S)-2-ethyl-N-(1-methoxypropan-2-yl)-6-methyl aniline with excellent selectivity starting from commercially available enantiopure (R)-epichlorohydrin [(R)-2] via formation of aziridine intermediate [(S)-4].

Patent No:: US9199930
Application No:: 14/426452
Filing Date:: 06-03-2015
Issue Date:: 01-12-2015
Applicant:: CSIR-National Chemical Laboratory (CSIR-NCL), Pune
Inventor(s):: Muthukrishnan Murugan; Prashant Pramod Mujumdar
IPC Classification:: C07C 213/02, C07D 203/14
Country:: United States of America

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