IN384529: Process for the preparation of Zafirlukast and analogs thereof
The invention relates to a process for the preparation of (l-alkylindol-3-ylmethyl) benzoic acid derivatives, in particular, Zafirlukast and analogs thereof. Further, this process is based on protection group free and C-H bond activation strategy involving all step catalytic transformation sequence and comprises the following steps: Sonogashira coupling, indole formation by Sp3C-H activation, reductive hydrogenation and amidation.
Patent No:
IN384529
Application No:
IN201711046976
Filing Date:
28-12-2017
Issue Date:
24-12-2021
Applicant:
CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad
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