US10752585: Process for the preparation of zafirlukast and analogs thereof
The invention relates to a process for the preparation of (l-alkylindol-3-ylmethyl) benzoic acid derivatives, in particular, Zafirlukast and analogs thereof. Further, this process is based on protection group free and C-H bond activation strategy involving all step catalytic transformation sequence and comprises the following steps: Sonogashira coupling, indole formation by Sp3C-H activation, reductive hydrogenation and amidation.
Patent No:
US10752585
Application No:
16/646462
Filing Date:
11-03-2020
Issue Date:
25-08-2020
Applicant:
CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad
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