US10336703: Process for the synthesis of ivacaftor and related compounds

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The patent discloses a novel one pot two-step process for the synthesis of ivacaftor and related compounds of [Formula (I)], wherein R1, R2, R3, R4, R5, R6, R7 and Ar1 are as described above; its tautomers or pharmaceutically acceptable salts thereof starting from indole acetic acid amides.

Patent No:: US10336703
Application No:: 15/573438
Filing Date:: 10-11-2017
Issue Date:: 02-07-2019
Applicant:: CSIR-National Chemical Laboratory (CSIR-NCL), Pune
Inventor(s):: Dumbala Srinivasa Reddy; Vasudevan Natarajan; Gorakhnath Rajaram Jachak
IPC Classification:: C07D 215/56, A61K 31/47, C07B 33/00, C07C 227/06
Country:: United States of America

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