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US10336703: Process for the synthesis of ivacaftor and related compounds

The patent discloses a novel one pot two-step process for the synthesis of ivacaftor and related compounds of [Formula (I)], wherein R1, R2, R3, R4, R5, R6, R7 and Ar1 are as described above; its tautomers or pharmaceutically acceptable salts thereof starting from indole acetic acid amides.
Patent No:
US10336703
Application No:
15/573438
Filing Date:
10-11-2017
Issue Date:
02-07-2019
Applicant:
CSIR-National Chemical Laboratory (CSIR-NCL), Pune
Inventor(s):
Dumbala Srinivasa Reddy; Vasudevan Natarajan; Gorakhnath Rajaram Jachak
IPC Classification:
C07D 215/56, A61K 31/47, C07B 33/00, C07C 227/06
Country:
United States of America
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