IN345265: Proteaseomal inhibitors useful for ostegenic activity and pharmaceutical composition thereof [osteo-heal]

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A method for prevention and/or treatment of diminution of bone tissue using a composition comprising a compound selected from Withaferin A (WFA), Withanolide A, and Withanone. The composition showed enhanced WFA bioavailability in rodents against plain WFA, promotes bone marrow cell differentiation, and increases the percent of bone volume to tissue volume (BV/TV%) by 3 folds as compared to free Withaferin A (WFA).

Patent No:: IN345265
Application No:: 2145DEL2013
Filing Date:: 17-07-2013
Issue Date:: 27-08-2020
Applicant:: CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow
Inventor(s):: Prabhat Ranjan Mishra; Ritu Trivedi; Divya Singh; Priyanka Kushwaha; Vikram Khedgikar; Sulekha Adhikari; Dharmendra Choudhary; Jyoti Swarup; Avinash Kumar; Anirudha Karvande; Ashwni Verma; Shweta Sharma; Prabodh Trivedi; Neelam S Sangwan; Rajendra S Sangwan
IPC Classification:: A61K 31/00
Country:: India

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