US11168084: Purine based compounds as toll-like receptor 9 antagonist

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The invention provides novel purine based compounds of formula 1, method of preparation of purine based compounds and its composition useful for inhibiting signalling through Toll-like receptors. These compounds are useful in inhibiting immune stimulation involving toll-like receptor 9 (TLR9). These can be used in treatment of autoimmune disease and inflammation where aberrant activation of TLR9 plays role.

Patent No:: US11168084
Application No:: 16760727
Filing Date:: 30-04-2020
Issue Date:: 09-11-2021
Applicant:: CSIR-Indian Institute of Chemical Biology (CSIR-IICB), Kolkata
Inventor(s):: Talukdar Arindam; Ganguly Dipyaman; Mukherjee Ayan; Paul Barnali; Rahaman Oindrila; Kundu Biswajit; Roy Swarnali; Deblina Raychaudhuri
IPC Classification:: C07D
Country:: United States of America

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