The invention relates to the alkylidene phosphonate esters of formula I wherein, R1 is selected from a group consisting of hydrogen or alkyl group; R2 is selected from a group consisting of hydrogen, hydroxy, alkyl, alkoxy, nitro, halogen, amino, N- substituted alkylamino; alkyl group is selected from a group consisting of methyl, ethyl and isopropyl; Ar is selected from a group consisting of aryl, substituted aryl, fused aryl, heteroaryl, and substituted heteroaryl. The invention particularly relates to synthesis and P-glycoprotein induction activity of the alkylidene phosphonate esters. In addition, the invention relates to methods of using compounds for treating or preventing Alzheimer's disease.
- Patent No:
- CA2961166
- Application No:
- 2961166
- Filing Date:
- 13-03-2017
- Issue Date:
- 13-03-2017
- Applicant:
- CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM), Jammu
- Inventor(s):
- Bharate Sandip, Kumar Ajay, Manda Sudhakar, Joshi Prashant, Bharate Sonali, Wani Abubakar, Sharma Sadhana, Vishwakarma Ram
- IPC Classification:
- A61K31/663, A61K31/665, A61P25/28, C07F9/40, C07F9/655
- Country:
- Canada
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