US9580452: An antioxidant compound having anti atherosclerotic effect and preparation thereof

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The invention relates to an antioxidant compound having anti atherosclerotic effect and preparation thereof. The invention more particularly relates to the synthesis of TPP+ coupled esculetin (Mitochondria-targeted esculetin [Mitb-Esc]) followed by the biological evaluation of Mito-Esc for its ability to attenuate Angiotensin-11-induced atherosclerosis in apolipoproteinE knockout (ApoE/_) mice along with the endothelial cell age-delaying effects of Mito-Esc.

Patent No:: US9580452
Application No:: 15/047,872
Filing Date:: 19-02-2016
Issue Date:: 28-02-2017
Applicant:: CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad
Inventor(s):: Kotamraju Srigiridhar, Karnewar Santosh, Vasamsetti Sathish Babu, Togapur Pavan Kumar, Basi Venkata Subba Reddy, Jerald Mahesh Kumar
Country:: United States of America

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