US10017511: Pyrazolopyrimidinones for the treatment of impotence and process for the preparation thereof

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The invention relates to Pyrazolopyrimidinone compounds as PDE5 inhibitors with better IC50 value, good in efficacy and PK profile and a process for the preparation thereof. The invention covers the pyrazolo pyrimidinone based compounds that have been designed, synthesized and screened for PDE5 inhibitory activity and its PDE5 inhibitory potential is provided in this invention. These designer compounds have shown nanomolar potency when screened for PDE5 inhibitory activity and also shown better in efficacy. These compounds can be used the treatment of male erectile dysfunction or the treatment of impotence.

Patent No:: US10017511
Application No:: 15/115573
Filing Date:: 16-07-2029
Issue Date:: 18-07-2010
Applicant:: CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM), Jammu
Inventor(s):: Sawant Sanghapal Damodhar; Ginnereddy Lakshma Reddy; Mahesuni Srinivas; Syed Sajad Hussain; Dar Mohd Ishaq; Nargotra Amit; Mahajan Priya; Vishwakarma Ram Asrey
IPC Classification:: A01N 43/90 20060101, A61K 31/51920060101, C07D 487/04 20060101
Country:: United States of America

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