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US8759339: Pyrrolo[2,1-c][1,4]naphthodiazepine linked piperazine compounds and a process for the preparation thereof

The invention provides a compound of general formula A, useful as potential antitumour agents against five human cancer cell lines. The invention further provides a process for the preparation of pyrrolo[2,1-c][1,4]naphthodiazepine linked substituted piperazine conjugates attached through different alkane spacers of general formula A. (Formula I) General formula A. Where R=R'=(Formula II). n=1-9 and R''=methyl, ethyl, acetyl, benzyl, piperinoyl, 4-fluorophenyl, 4-chlorophenyl, 4-methoxyphenyl, pyridyl, pyrimidyl.
Patent No:
US8759339
Application No:
13/985510
Filing Date:
13-08-2014
Issue Date:
14-06-2024
Applicant:
CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad
Inventor(s):
Ahmed Kamal; Jayanti Naga Srirama Chandra Murty; Arutla Viswanath
IPC Classification:
C07D 487/04, A61K 31/55
Country:
United States of America
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