US8841466: Series of artemisinin derivatives and process for preparation thereof

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This invention relates to the synthesis of certain novel Baylis-Hillman adducts of artemisinin-derived aldehyde 2-[10'?-deoxoartemisininyl]-ethanal. The capabilities of introduction of three functional groups into a molecule in one step using the Baylis-Hillman reaction encouraged us to synthesize some highly functionalized derivatives of artemisinin. These highly functionalised artemisinin derivatives embodied in this document are found to be active against various cancer cell-lines.

Patent No:: US8841466
Application No:: 13/574440
Filing Date:: 15-10-2012
Issue Date:: 23-09-2014
Applicant:: CSIR-North East Institute of Science and Technology (CSIR-NEIST), Jorhat
Inventor(s):: Gakul Baishya; Nabin Chandra Barua; Abhishek Goswami; Partha Pratim Saikia; Paruchuri Gangadhar Rao; Ajit Kumar Saxena; Nitasha Suri; Madhunika Sharma
IPC Classification:: C07D 321/00
Country:: United States of America

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