Patents

The invention relates to novel spiro-oxazine analogs of Formula-I and Indolinone compounds of Formula-II or positional isomers, or stereoisomers, or derivatives, or pharmaceutically acceptable salt thereof. Formula-I Formula-II further the invention provides transition-metal free Multicomponent Reaction (MCR) process for the preparation of said compounds of Formula-I and II using aryne precursor, N-substituted isatin and N-heteroaromatic compound as the nucleophile, under mild condition leading to the formation of the desired complex of spiro-oxazine analogs (I) and indolinone analogs (II) in high yield and selectivity.