Targeting nucleolin for refining anti-neoplastic chemo-immunotherapy and immunomodulation in B-Cell lymphoma
Implementing Organization
CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow
Principal Investigator
Dr Neeraj Jain
Scientist, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow
CO-Principal Investigator
Dr Gopal Chandra Kundu
Professor, Kalinga Institute of Industrial Technology (KIIT), Odisha, Dr Anurag Varshey, Head, University of Patanjali, Uttarakhand, Dr Manisha Naithani, Scientist, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, Dr Naveen Kumar Singhal, Scientist, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, Dr Uttam Kumar Nath, Scientist, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow
Project Overview
The study will understand in-depth functions of surface nucleolin in lymphoma biology, and this will determine alternative strategies to overcome chemotherapeutic resistance. The study will also analyses the importance of tumor cell specific surface nucleolin in maintaining stem cell phenotype and alternative strategies to target these cancer stem cell populations will be investigated.