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Validation and Translation of the Vaccines as well as Dignostic Technologies Developed on Phase of ADMaC

Implementing Organization

National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI)
Principal Investigator
Dr. Suresh KP
ICAR-National Institute of Veterinary Epidermiology and Disease Informatics (NIVEDI), Karnataka
suresh.kp@icar.org.in
Principal Investigator
Dr. Nagendra Nath Barman
College of Veterinary Sciences, AAU, Khanapara, Guwahati, Assam
nnbarman@gmail.com
Principal Investigator
Dr. Durlav Bora
Assam Agricultural University, Jorhat, Assam
drpankajaau@gmail.com
Principal Investigator
Dr. Pankaj Deka
College of Veterinary Sciences, AAU, Khanapara, Guwahati, Assam
brgulati@gmail.com
Principal Investigator
Dr. Baldev Gulati
National Research Centre on Equines, Hisar, Haryana
rajeswarishome@gmail.com
Principal Investigator
Dr. Seema Pegu
National Research Centre on Pig, Guwahati, Assam
girish@niab.org.in
Principal Investigator
Dr. Manoharan S
Tamil Nadu Veterinary and Animal Sciences University, Chennai
sureshkp97@rediffmail.com
Principal Investigator
Dr. Girish K Radhakrishnan
National Institute of Animal Biotechnology, Hyderabad
drseemapegu@yahoo.com
Principal Investigator
Dr. Rajeswari Shome
National Institute of Veterinary Epidemiology and Disease Informatics, Bengaluru, Karnataka
anoulagai@gmail.com
CO-Principal Investigator
Dr. Narayanan G
National Institute of veterinary Epidemiology and Disease Informatics, Bengaluru, Karnataka
durlav.bora@aau.ac.in
CO-Principal Investigator
Dr. Lukumoni Buragohain
College of Veterinary Sciences, AAU, Khanapara, Guwahati, Assam
lukummoni54@gmail.com
CO-Principal Investigator
Dr. Abhijit Deka
College of Veterinary Sciences, Assam Agricultural University, Jorhat, Assam
ramyavet@gmail.com
CO-Principal Investigator
Dr. Deep Saikia
College of Veterinary Sciences, AAU, Khanapara, Guwahati, Assam
saikiadeep17@gmail.com
CO-Principal Investigator
Dr. Nagalingam M
National Institute of veterinary Epidemiology and Disease Informatics, Bengaluru
drbiswajitkvk@gmail.com
CO-Principal Investigator
Dr. Ajay Yadav
National Research Centre on Pig, Guwahati, Assam
sophiagogoi@gmail.com
CO-Principal Investigator
Dr. Ramya Rajendran
Tamil Nadu Veterinary and Animal Sciences University, Chennai
dr.ajayyadav07@gmail.com
CO-Principal Investigator
Dr. Divakar Hemadri
National Institute of veterinary Epidemiology and Disease Informatics, Bengaluru
drrajibdeb@gmail.com
CO-Principal Investigator
Dr. Biswajit Dutta
College of Veterinary Sciences, AAU, Khanapara, Guwahati, Assam
drpranabjyotidas@gmail.com
CO-Principal Investigator
Dr. Sophia Gogoi
College of Veterinary Sciences, AAU, Khanapara, Guwahati, Assam
swaraj.rajkhowa@gmail.com
CO-Principal Investigator
Dr. Rajib deb
National Research Centre on Pig, Guwahati, Assam
gupta.drvivek@gmail.com
CO-Principal Investigator
Dr. Pranab Das
National Research Centre on Pig, Guwahati, Assam
docabhijit93@gmail.com
CO-Principal Investigator
Dr. Swaraj Rajkhowa
National Research Centre on Pig, Guwahati, Assam
divakar.hemadri@gmail.com
CO-Principal Investigator
Dr. Vivek Gupta
National Research Centre on Pig, Guwahati, Assam
sharanspin13@gmail.com
CO-Principal Investigator
Dr. S. S. Patil
National Institute of veterinary Epidemiology and Disease Informatics, Bengaluru
narayana.g@icar.gov.in
CO-Principal Investigator
Dr. R P Aravind Babu
Tamil Nadu Veterinary and Animal Sciences University, Chennai
aravindhvet@gmail.com
CO-Principal Investigator
Dr. Arijit Shome
Assam Agricultural University, Jorhat, Assam
arijitshome25@gmail.com

Project Overview

Major leads of Core Lab I (AAU, Guwahati) under ADMaC phase I include development of vaccinesagainst some of the endemic diseases like classical swine fever and Duck Plague. Again, importantleads were obtained under diagnostics which include both molecular as well as serological assaysthat could be used for early diagnosis of prevalent diseases.

Achievements

Cell culture adapted duck plague virus(DPV)vaccine candidate (DPV/As/Km/19)has been identified and its immunogenicity was evaluated by a control animal experiment in ducks. The vaccine produced promising antibody titre including neutralization titre upto day60 post immunization. Indirect ELISA for detection of specific antibodies against DPV,CSFV, PCV2, JEV, Brucella spp. And Coxiella burnetiid have been optimized by using recombinant protein or immunogenic peptides as coating antigen. A competitive ELISA having DIVA potential for multi species Brucellosis has been developed and validated. Three lateral flow assay(LFA)for detection of JEV, DPV and Brucella specific antibodies have also been optimized, and validation process with licencing formalities of LFA for Brucella antibody detection has been completed. One multiplex qPCR assay and one duplex qPCR assay(one for RNA viruses and other for DNA viruses of pigs) are standardized for detection of different swine viruses which includes, CSFV, PRRSV, ASFV, PCV2 and PPV. Both the multiplex/duplex PCR assays are highly sensitive and specific. Rapid nucleic acid-base assays such as PSR or LAMP have been optimized for detection of CSFV, PRRSV andPCV2and the run time for these assays is less than one hour and results could be obtained without any sophisticated instrument. Besides vaccine vaccines and diagnostic assays, two AI based mobile apps (PDDS & NERLDF) have been developed for livestock disease diagnosis and early disease forecasting to be used by veterinarians, para-vets and livestock farmers.

Source

Source
E-promis and Information received by Investigator

Related Research

View All
Funding Organization
Funding Organization
Department of Science and Technology (DBT)
Quick Information
Area of Research
Medical Sciences
Focus Area
Vaccines, Diagnostic Technologies
Start Date
31 Mar 2021
End Date
30 Sep 2025
Status
Completed
Email
suresh.kp@icar.org.in
Output
No. of Research Paper
00
Technologies (If Any)
00
No. of PhD Produced
00
Publications
01
No. of Patents
Filed : 00
Grant : 00
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