Research Projects

Worldwide, there are a lot of surgical procedures done, and the number keeps rising. According to a recent study, over 300 million surgical procedures were carried out in 2015, up 33.6% from the previous eight years. Trauma-related uncontrollable bleeding, which accounts for 50% of surgical deaths in cases involving service members, is the most common cause of death. As a result, lowering the death rate depends on the effective formation of stable hemostatic clots. In order to prevent infection and speed recovery, all wounds including those brought on by surgery need to be repaired and closed as soon as possible. The development of traditional surgical procedures has been significantly impacted by the increase in the need for effective hemostasis management and tissue sealing over the past few decades. Sutures with high tensile strength and low crack rates are still the most common technique for the majority of uninfected wounds. But for minimally invasive procedures, traditional suture materials like stitches, staples, or wires are not the best options. Although they are possible in general surgery, the method may result in the same unintended tissue injury and infection risk. Furthermore, it might not be possible to completely and immediately seal off the tissue to stop leaks of liquid and air, which would allow bodily fluids and air to enter delicate tissue like blood vessels and the lungs, liver, spleen, and kidney. These negative outcomes highlight the fact that current suture materials are not appropriate for challenging surgical procedures and may result in problems like a high infection rate, prolonged suture times, blood-borne illnesses, and adverse tissue reactions. Therefore, it is essential to develop surgery components that can be more straightforward and successful when performed with a minimally invasive technique. There is significantly number of researchers in identifying Sealants and Bioadhesives from various biological matters. In order to discover the appropriate bio-adhesives, many researchers are currently focusing their attention on aquatic organisms. The Scientists are believed that Aquatic organisms can produce effective bio adhesives in comparison with organisms because of its natural habitation. In this proposal we propose to develop high strength bio adhesives from one of the marine species known as Patellogastropoda, which is commonly known as Limpets. Based on the limpets survival behavior the limpets mucus could be used for temporary sealing of the bleeding as well it can also be used for permanent sealing depends upon the clinical requirement. In this proposed research project, our research team will mimic bio-adhesives derived from limpet mucus in order to seal and heal large surgical wounds.