Research Projects

Trauma is among the top 10 leading causes of death globally and accounts for 20% of global mortality. The pattern of injury varies from individual to individual based on the mechanism of injury and the anatomy of the individual. The dynamic nature of physiological perturbation and individual-specific response following severe injury make it challenging to predict the clinical course of the patients. Research in trauma helps to tackle the drawbacks in the system and aims to improve overall patient outcomes. Furthermore, precision medicine helps to improve the diagnosis of patients based on the metabolomics signature. Metabolomics is the study of small molecules such as amino acids, lipids, and carbohydrates which represent a physiological snap and ultimate interaction of the genome with environmental /physical stimuli Cytokines are small secreted proteins produced by nearly all cells to regulate and influence immune response. Excessive production of pro-inflammatory cytokines has been shown to be associated with the progression of various inflammatory and infectious diseases. In the current study, we will perform metabolic profiling of urine and plasma from trauma patients and will identify signature proinflammatory cytokines and complement factors C3 and C5 associated with final clinical outcomes following trauma. The outcome of the project will have clinical implications in improving the prognosis of trauma patients by blocking proinflammatory cytokine signaling that may facilitate adverse outcomes and fatality.