Post Graduate Institute Of Medical Education And Research, Chandigarh
vigimmc@gmail.com
CO-Principal Investigator
Dr. Amit Rawat
Post Graduate Institute Of Medical Education And Research, Madhya Marg, Sector 12,Chandigarh,Chandigarh-160012
CO-Principal Investigator
Dr. Saniya Sharma
Post Graduate Institute Of Medical Education And Research,Madhya Marg, Sector 12,Chandigarh,Chandigarh-160012
Project Overview
Juvenile dermatomyositis (JDM) is an autoimmune disorder characterized by B-cell abnormality, and type I IFN-stimulated genes (ISGs) are often overexpressed in JDM patients. While the causes of the IFN signature in JDM are not fully understood, they may be due to the activation of TLR7/TLR8 or TLR9 signaling pathways, genetic variations in the type I IFN pathway, or defects leading to the dysregulation of B cells. Type I IFNs have varied and cell-specific effects on mitochondrial metabolism, and studies have revealed mitochondrial and metabolic alterations in B cells. However, the effects of type I IFN signaling on human B-cell metabolism in-vivo remains to be determined in JDM.
Post Graduate Institute Of Medical Education And Research, Chandigarh
vigimmc@gmail.com
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