Research Projects

This project proposal primarily focused on generation of gold-coordinated and gold-carbene reactive intermediates and their further selective inter- and intramolecular annulations. Therefore, these gold reactive intermediates would easily facilitate polycyclic/ fused heterocyclic molecules in one pot those are difficult to synthesis in traditional synthetic protocols. The development of new synthetic techniques to generate application-oriented complex molecules is very important. There has been an increasing interest in gold-catalyzed organic reactions in recent years due to their selective transformations that can provide access to complex molecules and privileged molecular scaffolds. The main advantages of gold-catalyzed reactions are (i) high atom economy; (ii) gold catalysts can be tuned to achieve the regio/enantio selective reactions, (iii) Newly synthesized molecules will have different functional group which can be useful for further convections, (iv) Reduce the effluents, (v) The newly generated molecules will have chiral centre which many have important components in drug discovery program. Hence, identifying the versatile building blocks and explore under gold catalysts to expand their synthetic utility to produce the desired valuable scaffolds via annulations reactions is of current interest. Very few research groups are working on gold-promoted reactions and there are a lot of opportunities to explore to establish new synthetic transformations to access the valuable scaffolds. We are interested to explore the scope of gold-carbene intermediates to generate privileged molecular scaffolds by making new C-C, C-O and C-N bonds by designing and synthesizing the versatile new building blocks. Recently, we have developed gold-catalyzed synthetic strategies to generate various heterocyclic molecules which are core structures of biologically active molecules like cyclopropane-fused-tetrahydrobenzochromenes, indenylidene derivatives, vinyl-substituted pyrazolo[1, 4]-oxazepines, benzofulvenes, indenone derivatives, 2-hydroxybenzocarbazoles, pyrazolo[1,5-a]pyridines, 1H-isochromene-4-carbaldehydes, aminobenzophenone derivatives, chloroallyl carbazoles, aryl-fused pyrazolooxazepines, dihydroquinazolinones, 6-hydroxy indoles. We are very much interested to explore the gold-carbene reactive intermediates to generate fused heterocyclic molecules. Our intention of this proposal is to synthesize biologically active complex fused molecular scaffolds under homogeneous catalysis. From this project, we strongly believe that the developed strategic applications would have opportunity to explore sequential or tandem annulations by carefully utilizing the gold catalysts to access biologically valuable fused-polycyclic / heterocyclic or privileged molecule scaffolds, Active Pharma Ingredients (APIs) and new chemical entities which may have application in agrochemicals, medicinal chemistry and in material sciences.