Research Projects

The present proposal focuses on advancing photoredox-catalyzed synthetic organic chemistry by enabling novel activation pathways for bond formation, thereby creating new opportunities for molecular construction. This project specifically aims to explore the selective functionalization of alkynes via photoredox catalysis to generate diverse and biologically relevant scaffolds. Alkynes, as versatile structural motifs, play a crucial role in pharmaceuticals and natural products, yet their functionalization via photoredox pathways presents significant challenges. Addressing this, the proposed research aims to develop strategies for photoredox-catalyzed transformations of modular alkynes, focusing on hydrofunctionalization, cycloaddition, and the synthesis of highly functionalized heterocycles and allenes. Key target compounds include sulfur-containing heterocycles such as chromenes, thiochromenes, and isoxazolines, known for their anticancer, antimicrobial, and anti-inflammatory properties. Additionally, the synthesis of cyclobutene and allene derivatives expands the toolkit for constructing complex molecular architectures, with implications for drug discovery, agrochemicals, and materials science. The focus would also be on the late-stage functionalization of complex molecules, streamlining synthetic routes while aligning with green chemistry principles. The outcomes are expected to contribute to medicinal chemistry by providing access to bioactive compound libraries and advancing the development of next-generation pharmaceuticals. Furthermore, the project will support skill development in organic synthesis, preparing researchers to tackle emerging challenges in synthetic and medicinal chemistry.