The proposal is an attempt to develop the lanthanide activated (e.g. Nd3+, Ho3+) Li/NaErF4:Yb3+ and Li/NaErF4:Yb3+@) Li/NaErF4 core shell structure nanoparticles. The prepared nanoparticles are expected to have the emission in the optically transparent biological windows (BWs) of the electromagnetic spectrum i.e. (650 to 950 nm = BW-I, 1000 to 1350 nm = BW-II, 1500 to 1800 nm = BW-III). This anticipation is supported by the energy levels of the lanthanides intended to use during the nanoparticle synthesis. A simple chemical technique will be adopted for the synthesis with the biologically benign capping agents for biocompatibility. The proposal includes a thorough investigation of the structural, morphological, particle formation and size, etc. of the nanophosphors. Luminescent properties of the prepared samples will be examined in detail with the steady state luminescence and its dynamics along with the absolute quantum yield. The properly optimized nanophosphors will be tested for temperature sensing in different biological optical windows. The mechanism behind the temperature-dependent luminescence emission will be thoroughly investigated. Not limited to this, the time domain temperature sensing will also be investigated. It is also intended to observe the temperature sensing and measurement in the mimicked biological conditions.