Research Projects

This project aims to develop an efficient and scalable synthesis of complex natural products. By employing programmable and cascade transformations, the strategies will enable scalable routes to biologically significant targets, including Cryspatanolide, Euonyminol, and the anticancer drug Trabectedin. The strategies focus on step-economical, regio- and stereoselective functionalizations using functionally rich intermediates. Key methodologies include Au(I)-catalyzed protolactonization, selective-olefin functionalizations, and diketopiperazine-functionalization. Target-specific plans involve gram-scale synthesis of Cryspatanolide, decalin–agarofuran framework assembly for Euonyminol, and Trabectedin. This work advances selective functionalization and cascade reactivity principles while offering a general synthetic blueprint aligned with industrial needs. The platform is expected to streamline access to bioactive molecules and their analogs, supporting SAR studies and future drug discovery efforts.