Research Projects

Development of sustainable synthetic strategies for constructing complex molecular framework is highly exigent and trending in modern day chemical research. Numerous promising techniques have surfaced with photo-redox and electro-organic conversions garnering special global interest of industries and academics from a cost-effective and environmentally benign perspective. Visible light promoted photo-redox reactions have attracted a great deal of current attention due to its sustainable form of energy to promote organic transformations. Over the past decades, Ir+3 and Ru+2 complexes as well as organic dyes, that absorb the visible light, have been widely used in the standard photo-redox reactions. On the hand, the popularity of electricity as a reagent has shown growing interest in the development of more sustainable and efficient methods for the synthesis of complex organic molecules. The remarkable development of electron transfer processes in photo-redox/ electro-organic reactions involving radical/ radical ion intermediates, give rise to several valuable synthetic transformations to form C-C and C-X bonds. Owing to the tremendous promise in photo-redox/ electrolytic tools, chemists have started looking for challenging organic reactions which are practical, greener, and easy to scale up for the industrial processes. The present work plan envisions innovative synthetic strategies by means of photoredox/ electro-organic catalysis to explore some highly demanding organic transformations employing inexpensive and readily available reactants, followed by its applications to attain the significant molecules of biological and material interest. The research proposal comprises the following unique transformations: 1) Synthetic utilization of organic azides under photoredox conditions to accomplish a variety of useful products such as methyl 2-(5-aryloxazol-2-yl)acrylates, 3-(5-aryloxazol-2-yl)-2H-chromen-2-ones, methyl 2-oxo-4,6-diaryl-1,2-dihydropyridine-3-carboxylates, and pyrrolo[1,2-f]phenanthridines. 2) Synthesis of trifluoromethyl substituted oxazoles, indolin-2-ones, and pyrrolidine-2,5-diones utilizing Langlois’ Reagent under electro-redox conditions. 3) Synthesis of trifluoromethylated tetrasubstituted alkenes as well as cyclopropanes via cross coupling of hydrazones and α,β-unsaturated carbonyl compounds. 4) Synthesis of diverse pyrazoles by the reaction of hypervalent iodine and hydrazones; [3+2] cycloaddition of diazo compounds with arylacetylenes. 5) Construction of some biologically important compounds using indoles and its related heterocycles. 6) Strategic utilization of C-H activation to access the pyridoquinazolinones, oxazoles, keto-amides, benzyl cyanides, and enantioselective cyanides under electro-redox conditions.