Ultrasensitive molecular imprinted aptasensor based on mxene decorative nanostructure for simultaneously detection of microplastic and PFAS in water
Implementing Organization
Indian Institute Of Technology Kanpur
Principal Investigator
Dr. Bharti Sharma
Indian Institute Of Technology Kanpur
BHARTI19@KUK.AC.IN
Project Overview
Water is an essential components for all living organisms to survive. The availability of safe drinking-water is a real matter of concern all around the world due to continuous increase in global population and economic development. Approximately 26% of the world' population lacks access to safe and clean drinking water (He et al., 2021). Consequently, many of these communities rely on untreated drinking water sources such as wells, and rivers for sustainable development (drinking, sanitation, and cooking). Lacking access to clean water and contaminated water is likewise connected with many diseases (Grönwall & Danert, 2020), (Kirstein et al., 2021). Microplastic and Per- and poly-fluorine material (PFAS) are two major and emerging contaminate which pollute water and increase microbial contamination in water (Brahana et al., 2023). It is estimated that about 3.4 million people die every year from drinking water issues, according to the WHO report of 2015. In which Children accounted for 1.4 million of these deaths. Thus, it is imperative to solve the problem of decontaminating water from microplastic as well as chemical contaminants (PFAS). The health of humans is directly related to the socioeconomic progress of a country, which relies on good quality water. After 2019, India's commitment to supply fresh water to all households under the ‘Jal Jeevan Mission’ will accelerate the focus on safe and secure water supplies (Singh & Naik, 2024). The rising concerns about water quality and related human health hazards urge researchers to develop efficient and innovative monitoring systems for detecting MP and PFAS that are sensitive, specific, rapid, inexpensive, easy to use, and applicable for on-site detection. In the past two decades, researchers and commercial sectors have developed novel techniques, methods, and products that can be directly apply in nanosensors for better water quality and safety. The incorporation of nanomaterials such as MXenes (2D metal carbide) and nanostructures (nanoparticles) has deeply revolutionized the diversity and sensitivity of nanosensors. Among the various transduction technologies, electrochemical emission plays an impressive and significant role. Electrochemical-based detection offers high sensitivity, simplicity, negligible background noise, and rapid and reproducible response.Recently, research groups worldwide are reporting different approaches to enhancing the robustness and specificity of the nanosensor. Aptamer (Apt) is emerging as the most fascinating affinity receptor because of its remarkable characteristics, including ease of synthesis, specificity, and repeatability. In recent years, besides aptamers, researchers have focused on Molecular imprinted polymer systems in sensing probes. MIPs are synthetic polymer that exhibits specific recognition site design to bind selectively to a particularly target molecules.NPs and BM receptors for developing highly selective sensors for MP and PFAS.
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