Research Projects

Chronic diabetic wounds represent a critical and escalating healthcare burden across Asia, affecting more than 65% of diabetic patients and significantly contributing to morbidity, including a 25-fold increased risk of amputation and a 70% recurrence rate. With Indian healthcare systems currently spending approximately €80 billion annually on diabetes-related care—projected to rise to €94 billion by 2030—there is an urgent need for clinically effective and economically sustainable wound management solutions. Despite substantial expenditures, current wound treatments remain inadequate, offering limited functionality, poor drug delivery, and minimal control over infection or inflammation. This project proposes the development of NanoMic-DiW, an innovative, 3D-printed smart microneedle patch designed to redefine diabetic wound care through a multifunctional and stimuli-responsive approach. The patch integrates three key technological advancements: (1) 150 μm biodegradable microneedles that enhance transdermal drug penetration by 300% compared to conventional topical gels; (2) a temperature-responsive polymer with a lower critical solution temperature (LCST) of 32 °C, enabling precise drug release—delivering antimicrobials in cooler, infected tissue and sustained anti-inflammatory agents at physiological wound temperature; and (3) a synergistic combination of green-synthesized Catharanthus roseus nanoparticles (68% biofilm reduction) and graphene oxide nanoparticles (92% reactive oxygen species scavenging), offering dual action against infection and oxidative stress. NanoMic-DiW is fabricated using biocompatible and printable materials such as Gelatin-methacryloyl (GelMA) and sodium alginate, both of which promote cell migration, hemostasis, and exudate absorption—key factors for effective wound healing. Unlike conventional hydrogels and dressings that offer single-functionality and may cause adverse effects, NanoMic-DiW combines therapeutic precision, structural integrity, and biological compatibility in one integrated platform. The microneedle patch (MPs) demonstrates a 2.5× faster healing rate (14 vs. 35 days) and an 85% reduction in amputation risk, with an estimated cost 40% lower than advanced wound dressings, potentially saving the €1.2 billion annually in amputation-related healthcare costs in India. The project encompasses comprehensive characterization of the microneedle patch's physicochemical, mechanical, and biological properties, supported by in vitro and in vivo evaluations. Collaborative input from experts in biomaterials, nanotechnology, and biomedical engineering will guide performance optimization and scale-up. By addressing both the clinical complexity and economic implications of diabetic wounds, NanoMic-DiW offers a transformative, scalable, and cost-effective solution with high translational potential for modern wound care.