Research Projects

The proposed work focuses on intercepting the [2+2+1] nickelacycloadduct with various radicals generated using photoredox catalysis. The Ganesh group has studied the cycloadduct formation between alkene/alkynes and aldehydes. The objectives include the Ni0/photoredox-catalyzed difunctionalization of unsaturated substrates with aldehydes, PCET-mediated radical generation from diazo-compounds for the difunctionalization of unsaturated substrates, and its intramolecular version, triggering a spontaneous lactonization. The PCET-mediated radical generation from diazo-compounds for difunctionalization involves a photoredox-mediated three-component coupling of alkynes, aldehydes, and diazo compounds under visible-light irradiation. This method introduces structural complexity and highlights the synthetic utility of this light-driven difunctionalization strategy.