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Alkaloid, a class of naturally occurring organic nitrogen-containing bases, most commonly found in higher plants, though they are also present in the animal kingdom. Certain plant families are particularly rich sources of alkaloids, in particular Apocynaceae family is a good example. Strychnos camptoneura Gilg et Busse and Strychnos angustiflora Benth. are large liana medicinal plants found in West and northern Central Africa, as well as southern China. The Antirhine indole alkaloids present in their stem bark and root bark possess strong muscle relaxant properties and have been widely used in traditional medicine to treat conditions such as rheumatoid arthritis, traumatic injuries, and myasthenia gravis. Recent biological and pharmacological studies of the plant genus Alstonia have found a wide variety of activities such as antimicrobial, antimalarial, antioxidant, antidiabetic, anti-inflammatory, antidiarrheal, CNS depressant, antifertility, and antiprotozoal activities (J. Ethnopharmacol., 2014, 153, 1). To date, more than 400 chemical compounds have been identified from the genus Alstonia, including alkaloids, triterpenes, flavonoids, fatty acids, phenolic acids, lignans, and volatile oils. Among these alkaloids, particularly monoterpenoid indole alkaloids (MIAs) are regarded as the primary bioactive constituents and are the most prevalent in Alstonia species (Arab. J. Chem., 2023, 16,104857). Corynantheine-type alkaloids are principal constituents of Mitragyna speciosa, commonly known as kratom, and enantioselective total synthesis of (-) corynantheidine pseudoindoxyl is described for their distinctive pharmacological activities (J. Am. Chem. Soc. 2024, 146, 118-124), and flavoalkaloids exerted moderate antiplasmodial activities (Molecules 2020, 25, 2654). Antirhine core-containing alkaloids, which include numerous biologically active natural products, can be efficiently synthesized through strategic methods to produce larger quantities needed for biological research and analogs development. This approach also yields potent intermediate compounds during synthesis. Additionally, simplified structural analogs that retain biological activity can be designed and synthesized, offering potential alternatives to the original molecules.