Developmental Biology Inspired Tissue Engineering Protocol For Articular Cartilage
Implementing Organization
Indian Institute of Technology (IIT)
Principal Investigator
Dr. Amitabha Bandyopadhyay
Indian Institute of Technology (IIT), Kanpur, India
CO-Principal Investigator
Prof. Sourabh Ghosh
IIT Delhi
About
Tissue engineering strategies attempt to develop preformed engineered constructs replicating the anatomical architecture, biological and mechanical functionality of the target tissue as faithfully as possible. However even after 30 years of tissue engineering efforts a clinically relevant, functionally equivalent engineered joint cartilage tissue construct for load bearing applications could not be prepared. This proposal envisages a paradigm shift in cartilage tissue engineering strategies using 3D bioprinting by recapitulating the developmental program in a biomimetic way to develop phenotypically stable articular cartilage that is molecularly indistinguishable from native articular cartilage.
Patents
NO
Achievements
Produced the first 3D Bio-printed cartilage which is molecularly similar to developing embryonic cartilage
Outcome / Output
The grant period is yet to be over. Developed a protocol for generating joint cartilage in petridishes
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