Investigating The Molecular Mechanism, Downstream Of Wnt Signaling,Of Articular Cartilage Differentiation

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Implementing Organization

Indian Institute of Technology (IIT), Kanpur

Principal Investigator

Dr. Amitabha Bandyopadhyay

Indian Institute of Technology (IIT), Kanpur, India

About

This proposal attempts to elucidate the molecular mechanism downstream of Wnt signaling that is critical for joint cartilage development and maintenance. Successful execution of this proposal will not only uncover some longstanding questions in the field of joint cartilage development but is also likely to open up novel approaches for treating osteoarthritis.

Patents

Achievements

1- Identified the first transcription factors capable of inducing joint cartilage formation. Also proposed a mechanism for co-ordination of transient and permanent cartilage differentiation. 2 – Solved a six decade old problem where we uncovered the molecular basis for loss of molecular property of joint cartilage upon immobilization of an embryo.

Outcome / Output

Discovered two novel transcription factors involved in joint cartilage formation.

Publications

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Funding Organization

Department of Science and Technology (DST)

Quick Information

Area of Research

Medical Sciences

Focus Area

Tissue engineering

Start Year

2016

End Year

2019

Sanction Amount

₹ 78.18 L

Status

Completed

Contact

abandopa@iitk.ac.in

Output

No. of Research Paper

Technologies (If Any)

No. of PhD Produced

No. of Patents

Filed : 00

Grant : 00

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Research Projects