Investigating The Role Of Bmp Signaling In Pathogenesis Of Osteoarthritis

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Implementing Organization

Indian Institute of Technology (IIT), Kanpur

Principal Investigator

Dr. Amitabha Bandyopadhyay

Indian Institute of Technology (IIT), Kanpur, India

About

Osteoarthritis is by far the most common disease afflicting the musculo-skeletal system. At present this disease is only treated symptomatically and in extreme cases by prosthetic replacement. No disease modifying therapy is available. In this proposal I plan to investigate if ectopic exposure of articular cartilage to BMP signaling can induce osteoarthritis in mouse. Based on several lines of argument we hypothesize that adult stage trans-differentiation of articular/permanent cartilage, induced by BMP signaling, causes osteoarthritis. If this hypothesis turns out to be true it can immediately suggest possible disease modifying therapy for osteoarthritis.

Patents

Achievements

Work in progress – possible pharmacological disease modifying therapy for osteoarthritis.

Outcome / Output

Work in progress

Publications

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Funding Organization

Department of Biotechnology (DBT)

Quick Information

Area of Research

Medical Sciences

Focus Area

Tissue engineering

Start Year

2017

End Year

2020

Sanction Amount

₹ 70.62 L

Status

Completed

Contact

abandopa@iitk.ac.in

Output

No. of Research Paper

Technologies (If Any)

No. of PhD Produced

No. of Patents

Filed : 00

Grant : 00

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Research Projects