Scientist, CSIR-Institute of Microbial Technology, Chandigarh
Project Overview
The aim of this grant application is to understand the role of SARS-CoV-2 Orf3a in modulating host cell responses. To achieve this, the following objectives will be pursued: (i) determine Orf3a localisation in host cells and delineate sorting motifs required for its intracellular trafficking; and (ii) elucidate the significance of Orf3a interaction with candidate host endosomal-lysosomal proteins.