Microfluidic platform for continuous monitoring of gasotransmitters for early level management of Systemic Inflammatory Response Syndrome (SIRS) in Trauma patients
Implementing Organization
Indian Institute of Technology (IIT)
Principal Investigator
Dr. Ashis Kumar Sen
Associate Professor
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Department of Metallurgical and Materials Engineering, Indian Institute of Technology (IIT), Chennai, Tamil Nadu
CO-Principal Investigator
Paul Ramesh Thangaraj
Apollo Hospitals, Chennai
Cardiothoracic Surgeon
CO-Principal Investigator
Jayashree Gopal
Apollo Hospitals, Chennai
CO-Principal Investigator
Anil Tarigopula
Apollo Hospitals, Chennai
CO-Principal Investigator
Dr. Madhulika Dixit
Associate Professor
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Department of Metallurgical and Materials Engineering, Indian Institute of Technology (IIT), Chennai, Tamil Nadu
CO-Principal Investigator
Muraleedharan K. M.
Department of Metallurgical and Materials Engineering, Indian Institute of Technology (IIT), Chennai, Tamil Nadu
CO-Principal Investigator
Anil Prabhakar
Department of Metallurgical and Materials Engineering, Indian Institute of Technology (IIT), Chennai, Tamil Nadu
CO-Principal Investigator
Dr. Ananth Krishnan
Department of Metallurgical and Materials Engineering, Indian Institute of Technology (IIT), Chennai, Tamil Nadu
Project Overview
One-third of all in hospital patients, greater than 50% of all ICU patients and more than 80% of surgical ICU patients suffer from SIRS induced morbidity and mortality with diminishing chances of survival due to delayed diagnosis and poor prognosis. Microbial tests are time consuming and the currently available biochemical markers lack specificity and can detect only at later stages of sepsis. Thus, early diagnosis of SIRS in acute trauma patients is mandatory for effective management. In this project, a microfluidics based novel Lab on Chip (LOC) platform will be developed for continuous monitoring of vascular gasotransmitters with high selectivity, specificity and accuracy for detecting SIRS. The aim is also intended to understand the interrelationship between gasotransmitters, for studying the endothelial function and clinical outcomes in SIRS signaling.
Indian Institute of Technology (IIT)
Associate Professor
Cardiothoracic Surgeon
Acces sibility Controls