Scientist, CSIR-National Chemical Laboratory (CSIR-NCL), Pune
Objective: To produce glycation resistant proteoforms of insulin by site-directed mutagenesis of lysine and arginine residues. To evaluate the binding and activity of recombinant insulin in vitro by using biophysical and cell-based assays . To evaluate the in vivo efficiency, pharmocokinetics and immune response of recombinant insulin using diabetic rat model. To perform preclinical (toxicological studies) using diabetic rat models.
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