Scientist, CSIR-Institute of Genomics & Integrative Biology (CSIR-IGIB), New Delhi
Objective: To study the effect of (1a) miR-29 mimic (1b) miRNA against anti-interferon gamma mRNA and (1c) anti-VDAC1 peptide (developed by international collaborator) in reducing the expression of interferon gamma induced genes in cell lines and in vivo mouse brain. To generate an (2a)AAV9-TBP system (2b) AAV9-HTT system with embedded intrans containing shRNA against the endogenous gene. Evaluate the efficacy of agents developed in (1) and (2) on HTT mice to revert neurodegeneration and ataxia.
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