To study gene expression for vitamin d receptor (VDR) and calcium sensing receptor (CaSR) in patients with primary hyperparathyroidism (PHPT) and its correlation with clinical outcome
Implementing Organization
Principal Investigator
Dr. Sanjay Kumar Bhadada
Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh
CO-Principal Investigator
Dr. Madhu Khullar
Professor
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Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh
CO-Principal Investigator
Dr. Uma Nahar Saikia
Additional Professor
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Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh
CO-Principal Investigator
Dr. Naresh Sachdeva
Assistant Professor
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Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh
Project Overview
The present findings showed significant reductions in VDR mRNA expressions in adenomatous compared to normal parathyroid tissue. Consistent with these, immunohistochemistry also revealed reduction at both nuclear as well as cytoplasmic expression in adenoma cells.