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Bioinformatic and structure-based approach towards developing low molecular weight proteins with nuclease and translational-Inhibitory activities as new potential anticancer agents

Implementing Organization

Aravind Medical Research Foundation
Principal Investigator
Dr. Gowri Priya Chidambaranathan
Scientist
|
Madurai, Tamilnadu
Aravind Medical Research Foundation (AMRF)

Project Overview

Regulation of nuclear transcription factor, ?Np63? by miR-203 has been reported in skin keratinocytes. In our investigation in non keratinized LESCs, we also report similar findings and have shown marked reduction in ?Np63? expression level after ectopic expression of miR-203. Moreover functionally the colony forming efficiency of miR-203 transfected cultured primary limbal epithelial cells were found to be reduced drastically. By repressing miR-203 with antagomicR treatment the colony forming efficiency has been rescued, and ?Np63? expression level was found to be high.

Related Research

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Funding Organization
Funding Organization

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Quick Information
Area of Research
Medical Sciences
Focus Area
Stem Cell Research
Start Year
2015
End Year
2017
Status
Completed
Output
No. of Research Paper
00
Technologies (If Any)
00
No. of PhD Produced
N/A
Startup (If Any)
00
No. of Patents
Filed :00
Grant :00
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