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Designing of hybrid molecules for various targets of inflammatory disorders using computer aided molecular modeling

Implementing Organization

Institute of Genomics and Integrative Biology (IGIB)
Principal Investigator
Dr. Srinivasan Ramachandran
Scientist
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Institute of Genomics and Integrative Biology (IGIB)

Project Overview

New compound alpha keto pimelic acid (KPA) has been assayed for inhibition of dapA. This compound displays time-dependent inhibition and kinetic studies show this inhibitor act as a competitive inhibitor against substrate pyruvate that has not previously been observed for inhibition of dapA. Therefore, this scaffold could have the potential to inhibit Mtb dapA would represent promising starting point as lead compound and certainly aid the experimental designing of antitubercular in lesser time.

Related Research

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Funding Organization
Funding Organization

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Quick Information
Area of Research
Life Sciences & Biotechnology
Focus Area
Bioinformatics
Start Year
2012
End Year
2015
Status
Completed
Output
No. of Research Paper
00
Technologies (If Any)
00
No. of PhD Produced
N/A
Startup (If Any)
00
No. of Patents
Filed :00
Grant :00
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