Studies on macrophage-T cells interaction in mouse model of malaria: Role of Th17 cells
Implementing Organization
National Institute of Malaria Research (NIMR), New Delhi
Principal Investigator
Dr. Jyoti Das
Scientist
|
National Institute of Malaria Research (NIMR), New Delhi
CO-Principal Investigator
Dr. T Adak
Scientist
|
National Institute of Malaria Research (NIMR), New Delhi
About
The blood stage malaria infection by Plasmodium berghei activates various immune cells. Somehow these activated cells differentiate into Treg, and the factors that drive t cell expansion or differentiation is unknown. We found high levels of CD4+ICOS+Foxp3+ cells, which are highly immunosuppressive in nature. We also observed that there is predominant secretion of IL-10 as the parasitic load increases which suppresses the immune activation and allows the parasite to grow in the host leading to its demise.
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National Institute of Malaria Research (NIMR), New Delhi
Scientist
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