ISTI LOGO
Towards a new dawn
×

img Acces sibility Controls

Research Projects Banner

Research Projects

Studies on macrophage-T cells interaction in mouse model of malaria: Role of Th17 cells

Implementing Organization

National Institute of Malaria Research (NIMR), New Delhi
Principal Investigator
Dr. Jyoti Das
Scientist
|
National Institute of Malaria Research (NIMR), New Delhi
CO-Principal Investigator
Dr. T Adak
Scientist
|
National Institute of Malaria Research (NIMR), New Delhi

Project Overview

The blood stage malaria infection by Plasmodium berghei activates various immune cells. Somehow these activated cells differentiate into Treg, and the factors that drive t cell expansion or differentiation is unknown. We found high levels of CD4+ICOS+Foxp3+ cells, which are highly immunosuppressive in nature. We also observed that there is predominant secretion of IL-10 as the parasitic load increases which suppresses the immune activation and allows the parasite to grow in the host leading to its demise.

Related Research

View All
Funding Organization
Funding Organization

—

Quick Information
Area of Research
Medical Sciences
Focus Area
Malaria
Start Year
2011
End Year
2015
Sanction Amount
₹ 29.10 L
Status
Completed
Output
No. of Research Paper
00
Technologies (If Any)
00
No. of PhD Produced
N/A
Startup (If Any)
00
No. of Patents
Filed :00
Grant :00
arrowtop